Government Of The United States

PERFORMANCE-BASED CONTRACT FOR MANAGEMENT AND OPERATION OF ARGONNE NATIONAL LABORATORY

PHARMACEUTICALS AND RELATED SUPPLIES UNITED STATES DEPARTMENT OF DEFENSE:1133869 [26-003472]

UNICOR TASK CHAIRS FOR SPECIFIED INSTITUTIONS.

8511713986!T-SHIRT, AF MEN'S PTG

CAPITAL GALLERY RENT

THIS TASK ORDER IS THE PRIME TASK ORDER CALLED THE USAID SOUTHERN AFRICA COVID19 RESPONSE PRIME TASK ORDER AND SUPPORTS THE AMERICAN RESCUE PLAN ACT ENACTED BY THE U.S. PRESIDENT BIDEN. THE PURPOSE OF THIS TASK ORDER IS TO PROVIDE TECHNICAL AND ADMIN

FOLDER,FILE

OFFICE FURNITURE

BUILDINGS 300, 316 - SPACE MODERNIZATION FURNITURE

SOLAR B X RAY TELESCOPE PHASE E

GSA

CEREMONIAL HONOR GUARD OFFICE FURNITURE OUTFIT WITH DELIVERY AND INSTALLATION

NON PRODUCTION

STATEMENT OF WORK – PROJECT 3 OBJECTIVES. WE WILL TARGET HUMAN-SWINE INTERFACES IN MAJOR SWINE PRODUCTION REGIONS IN THE US, EUROPE, AND ASIA. COORDINATED SURVEILLANCE WITH SWINE AND HUMAN SAMPLE COLLECTION THAT LEVERAGES EXISTING SURVEILLANCE [E.G., US DEPARTMENT OF AGRICULTURE (USDA) NATIONAL IAV IN SWINE (IAV-S) SURVEILLANCE SYSTEM AND VETERINARY DIAGNOSTIC LABS] WILL ALLOW US TO QUANTIFY DRIVERS OF IAV EVOLUTION IN THE SWINE HOST. OUR OVERALL OBJECTIVE IS TO DEVELOP A RISK FRAMEWORK THAT ARTICULATES HOW ANTIGENIC DIVERSITY AND OTHER PHENOTYPIC PROPERTIES OF CIRCULATING SWINE IAVS AFFECT HUMAN PANDEMIC POTENTIAL AND INTERSPECIES TRANSMISSION. WE WILL DETERMINE THE PUBLIC HEALTH RISK OF CIRCULATING AND EMERGING IAVS IN GLOBAL SWINE POPULATIONS BY A COORDINATED AND SYSTEMATIC PIPELINE OF IN SILICO, IN VITRO, AND IN VIVO TESTING AND ANALYSES. SWINE IAV ISOLATES IDENTIFIED AS UNIQUE THROUGH SURVEILLANCE AND IN VIVO ANALYSES WILL BE CHARACTERIZED BY A IN VIVO AND IN VITRO PANDEMIC POTENTIAL PIPELINE AMONG CEIRR INVESTIGATORS. APPROACH. THIS OBJECTIVE WILL BE ACCOMPLISHED WITH 4 STREAMS OF SWINE VIROLOGIC DATA: 1) ACTIVE SURVEILLANCE IN CAMBODIA; 2) ACTIVE AND PASSIVE SURVEILLANCE IN THE UK; 3) ACTIVE AND PASSIVE SURVEILLANCE IN THE USA; AND 4) LEVERAGING THE USDA SURVEILLANCE SYSTEM AND ESTABLISHED SWINE INFLUENZA NETWORKS. HUMAN SAMPLING WILL OCCUR AT THE SWINE INTERFACE IN CAMBODIA AND THE USA. SEROLOGIC SPECIMENS WILL BE USED FROM OCCUPATIONALLY EXPOSED HUMAN COHORTS TO EVALUATE ANTIBODY RESPONSES TO SWINE IAV AND COMPARE TO URBAN HUMAN COHORTS. SEQUENCE ANALYSIS OF IAV-S WILL BE SUPPORTED BY DEDICATED SWINE COMPUTATIONAL EXPERTISE AND ANTIGENIC AND PHENOTYPIC CHARACTERIZATION OF SWINE IAV FOR ASSESSMENT OF RISK TO HUMANS CONDUCTED IN AND IN VIVO AND IN VITRO PANDEMIC POTENTIAL PIPELINE. EACH OF THESE COMPONENTS WILL CONTRIBUTE TO DEVELOPMENT OF A RISK RANKING METHOD FOR SWINE IAV. METHODS. AIM 1. INVESTIGATE DYNAMICS OF IAV AT HUMAN-SWINE INTERFACES THROUGH: A) LONGITUDINAL SURVEILLANCE FROM RELEVANT SWINE POPULATIONS AND HUMAN-SWINE INTERFACES TO INCLUDE CHARACTERIZATION OF IAV GENETIC DIVERSITY; AND B) COLLECTION OF OCCUPATIONALLY EXPOSED HUMAN COHORT SERA AND VIROLOGIC ASSESSMENT OF INTERSPECIES TRANSMISSION. AIM 2. DEVELOP PHYLOGENETIC ALGORITHMS THAT RAPIDLY IDENTIFY NOVEL REASSORTED VIRUSES, QUANTIFY VIRAL DIVERSITY BETWEEN SWINE AND HUMAN IAV, AND IDENTIFY SWINE IAV STRAINS TO TEST FOR ANTIGENIC ADVANCE OR INCREASED REPLICATION AND TRANSMISSION IN SWINE. AIM 3. ANTIGENIC AND PHENOTYPIC CHARACTERIZATION OF SWINE IAV FOR RISK TO HUMANS BY CHARACTERIZING VIRAL PROPERTIES IN THE SWINE HOST, SWINE-TO-FERRET TRANSMISSION, KEY PREDICTORS OF THE PANDEMIC RISK OF SWINE IAV, AND OTHER DOWNSTREAM MEDIATORS VIA COLLABORATION WITH CEIRR INVESTIGATORS. SCHEDULE. EACH OF THE INVESTIGATORS AND SITE LEADERS IN THIS PROJECT HAVE ESTABLISHED PROGRAMS TO QUICKLY IMPLEMENT SAMPLE FLOW FOR OUR CEIRR PROJECT. CLINICAL SAMPLES FROM LONGITUDINALLY SAMPLED SWINE WILL BE EVALUATED PERIODICALLY THROUGHOUT EACH YEAR, WHEREAS PASSIVE SURVEILLANCE BASED ON ROUTINE SUBMISSIONS TO THE VETERINARY DIAGNOSTIC LABORATORIES PARTICIPATING IN THIS PROPOSAL WILL IMMEDIATELY BEGIN TO ENTER THE PROJECT. VIRAL EVOLUTION AT THE GENETIC AND ANTIGENIC LEVELS WILL BE ASSESSED AT LEAST BI-ANNUALLY TO SELECT STRAINS FOR FURTHER CHARACTERIZATION. AUTOMATED SEQUENCE AND DATA ANALYSIS ALGORITHMS WILL BE DEVELOPED AND IMPLEMENTED TO ASSIST IN THE SELECTION PROCESS. EACH YEAR, SWINE AND FERRET SERA WILL BE RAISED FOR ANTIGENIC CHARACTERIZATION OF UP TO 6 UNIQUE SWINE IAV AND TO TEST AGAINST HUMAN POPULATION SERA, UP TO 3 STRAINS WILL BE ASSESSED FOR PHENOTYPING IN THE SWINE HOST, AND UP TO 2 STRAINS WILL BE ASSESSED FOR AEROSOL TRANSMISSION BETWEEN SWINE AND FERRETS. SWINE IAV RANKED AS HIGHER RISK FOR HUMANS WILL BE SHARED AMONG CEIRR INVESTIGATORS FOR DOWNSTREAM RISK ASSESSMENT STUDIES AND POTENTIAL PUBLIC HEALTH ACTION.

BK-0008 HPR NON-TOUCH LABOR BK-0008 HPR TOUCH LABOR BK-0009 HPR NON-TOUCH LABOR BK-0009 HPR TOUCH LABOR BK-0012 HPR NON-TOUCH LABOR BK-0012 HPR TOUCH LABOR