University Of Pittsburgh - Of The Commonwealth System Of Higher Education

PROVIDE DEFINITIVE EVIDENCE ON THE EFFECTIVENESS, SAFETY, AND MECHANISMS OF LOW TITER GROUP O WHOLE BLOOD (LTOWB) AND TRANEXAMIC ACID (TXA) AS RESUSCITATION STRATEGIES FOR THE TREATMENT OF LIFE-THREATENING BLEEDING SECONDARY TO TRAUMATIC INJURY IN CH

SEMI CLOSED LOOP CONTROL CARDIOVASCULAR RESUSCITATION FOR PROLONGED FIELD CARE RESEARCH PROJECT/AWARD

EO 14398 HERL/WARE TECH TRANSFER ASSISTED PROGRAM

RESEARCH IAW SOW (BASE)AWARD TO UPITT (BG PLUS)

RESEARCH IAW SOW (BASE)AWARD TO UPITT (BG PLUS)

PHYSIOLOGIC AGE OF WHOLE BLOOD

PREHOSPITAL AIRWAY CONTROL TRIAL BASE AWARD

PREHOSPITAL AIRWAY CONTROL TRIAL BASE AWARD

THE PAIN TRIAL IS A 4 YEAR (3-YEAR ENROLLMENT) MULTICENTER, PREHOSPITAL, RANDOMIZED, DOUBLE-BLIND, CLINICAL TRIAL COMPARING FENTANYL VERSUS SUB-DISSOCIATIVE KETAMINE FOR MORTALITY OUTCOME DIFFERENCES, SAFETY, AND ANALGESIA IN TRAUMA PATIENTS WITH COMPENSATED SHOCK.

NEW LITES ORDER TASK ORDER 0010 CAVALIER TRIAL

NEW LITES ORDER TASK ORDER 0010 CAVALIER TRIAL

PREHOSPITAL AIRWAY CONTROL TRIAL BASE AWARD

UNIVERSITY OF VERMONT WILL PARTICIPATE IN THE PERFORMANCE OF A PROSPECTIVE, INTERVENTIONAL, RANDOMIZED TRIAL AMONG PREHOSPITAL TRAUMA PATIENTS WITH COMPENSATED SHOCK (SI>0.9) AND AN INDICATION FOR PAIN MANAGEMENT COMPARING KETAMINE HYDROCHLORIDE VERSUS FENTANYL CITRATE PER ATTACHMENT 3 OF THIS AGREEMENT.

SERVE AS A CLINICAL SITE FOR TASK ORDER 006: PREHOSPITAL ANALGESIA INTERVENTION (PAIN) TRIAL, A 4 YEAR (3-YEAR ENROLLMENT) MULTICENTER, PREHOSPITAL, RANDOMIZED, DOUBLE-BLIND, CLINICAL TRIAL COMPARING FENTANYL VERSUS SUB-DISSOCIATIVE KETAMINE FOR MORTALITY OUTCOME DIFFERENCES, SAFETY AND ANALGESIA IN TRAUMA PATIENTS WITH COMPENSATED SHOCK.

NEW LITES ORDER TASK ORDER 0010 CAVALIER TRIAL

PCL-02 M3 SUBCONTRACTS

LE SAGE SCOPE OF WORK FOR PENN-CEIRR OPTION 18.L THIS CEIRR CONCEPT PROPOSAL HAS TWO DISTINCT AIMS THAT WILL ENABLE CHARACTERIZATION OF H5N1 HIGHLY PATHOGENIC AVIAN INFLUENZA (HPAI) VIRUS IN TERMS OF HOST AND ENVIRONMENTAL FACTORS THAT AFFECT TRANSMISSIBILITY. H5N1 HPAI STRAINS THAT ARE IMPORTANT TO THE DAIRY CATTLE OUTBREAK WILL BE ASSESS IN THE FOLLOWING AIMS. THERE ARE MANY IN VITRO CHARACTERISTICS THAT HAVE AN IMPACT ON EFFICIENT TRANSMISSION OF INFLUENZA VIRUS. IN AIM 1, I WILL CHARACTERIZE H5N1 HPAI STRAINS TO BETTER UNDERSTAND HOST TROPISM AND ENVIRONMENTAL STABILITY. THE FOLLOWING TASKS WILL BE ACCOMPLISHED: 1. EXAMINE REPLICATION KINETICS OF H5N1 HPAI IN PRIMARY HUMAN AIRWAY EPITHELIAL CELLS AND COMPARE IT TO A SEASONAL INFLUENZA VIRUS. 2. PERFORM SINGLE CELL RNA SEQUENCING ON THE INFECTED PRIMARY HUMAN AIRWAY EPITHELIAL CELLS TO COMPARE HOST TROPISM BETWEEN H5N1 HPAI AND SEASONAL INFLUENZA VIRUS. 3. COMPARE THE SECRETED CYTOKINES AND CHEMOKINES FROM H5N1 HPAI OR SEASONAL INFLUENZA VIRUS INFECTED PRIMARY HUMAN AIRWAY EPITHELIAL CELLS USING LUMINEX ASSAY. 4. DETERMINE THE ENVIRONMENTAL STABILITY UNDER A RANGE OF RELATIVE HUMIDITIES IN STATIONARY DROPLETS THAT CONTAIN MUCUS, COLLECTED FROM PRIMARY HUMAN AIRWAY EPITHELIAL CELLS. PRE-EXISTING IMMUNITY IS AN IMPORTANT BARRIER TO INFLUENZA VIRUS TRANSMISSION. IN AIM 2, I WILL ASSESS THE IMPACT OF SEASONAL VACCINATION IN FERRETS PRIOR TO CHALLENGE WITH H5N1 HPAI. THE FOLLOWING TASKS WILL BE ACCOMPLISHED: 1. PERFORM FERRET PATHOGENESIS AND SURVIVAL STUDIES IN FERRETS THAT HAVE BEEN VACCINATED WITH A SEASONAL INFLUENZA VIRUS THREE MONTHS PRIOR TO INTRANASAL CHALLENGE. 2. AS AIRBORNE TRANSMISSION IS NOT EFFICIENT FOR HPAI STRAINS, I WILL LEVERAGE THE AEROBIOLOGY CORE AT THE UNIVERSITY OF PITTSBURGH TO COMPARE THE SUSCEPTIBILITY OF VACCINATED FERRETS TO AEROSOL CHALLENGE OF H5N1 HPAI CHALLENGE. 3. PERFORM SEROLOGICAL ASSAYS TO DETERMINE THE LEVELS OF CROSS-REACTIVE HA AND NA ANTIBODIES GENERATED BY THESE VACCINATED FERRETS BEFORE AND AFTER CHALLENGE.